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In the absence of such information, we are reduced to rerunning the model from the start many times, pausing at various points in order to observe intermediate states and see where its behavior diverges from what we expect.
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Information Go online to www. As already described, abrogation of the G2 checkpoint using caffeine in cells that were competent or deficient in G1 checkpoint control (by manipulation of p53 using E6) further sensitized wild type p53 cells or corrected the radioresistance in E6-inactivated cells [30,31] and there are a number of reports of radiosensitization by manipulation of the G2 checkpoint in a background of p53 deficiency.
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